Azithromycin Dihydrate is an antibiotic useful for the treatment of bacterial infections. It is a BCS class II drug and its bioavailability is about 40-45%. The present aim of this formulation was to formulate solid self-emulsifying drug delivery system to improve the solubility and bioavailability of azithromycin dihydrate. The liquid (SEDDS) consisted of clove oil as oil phase, tween 20 as surfactant and ethanol as co-surfactant. Oil, surfactant and co-surfactant were selected on the basis of solubilization capacity of drug and emulsification ability of surfactant and co-surfactants. The formulations were optimized by constructing the pseudo-ternary phase diagram. The liquid formulation was solidified by adsorption technique, using magnesium hydroxide as solid carrier. There are many techniques to convert liquid SMEDDS to solid, but an adsorption technique is simple and economic. Drug releases from S-SMEDDS were found to be significantly higher as compared with that of plain azithromycin dihydrate. Study concluded that S-SMEDDS can effectively formulated by adsorption technique with enhanced dissolution rate and concomitantly bioavailability.
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